2-deoxy-D-Glucose-(2-DG) Prevents Pathogen Driven Acute Inflammation and Associated toxicity
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چکیده
منابع مشابه
Acute toxicity and cardio-respiratory effects of 2-deoxy-D-glucose: a promising radio sensitiser.
OBJECTIVE To evaluate the acute toxicity of 2-deoxy-D-glucose (2DG) by oral (p.o.) and intravenous (i.v.) routes, and also the cardio-respiratory effects following high doses of 2DG in animal models. METHODS The LD50 of 2DG (in water) was determined in rats and mice by p.o. route and in mice by i.v. route. The effect of 2-DG (250 mg/kg, 500 mg/kg, and 1000 mg/kg, i.v.) was studied on various ...
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Introduction: This report describes the synthesis of 2-Amino-2-deoxy(S-benzoylthioacetyl)-D-glucose (S-Bz-TA-DG), radiolabeled with [99mTc(CO)3(OH2)3]+ complex with a procedure including deprotection of the benzoyl group, characterization by HPLC using a C18 reverse phase column and preliminary biodistribution study in normal ...
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BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
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2-Deoxy-2-fluoro-d-glucose (FDG) is glucose analog routinely used in clinical and animal radiotracer studies to trace glucose uptake but it has rarely been used in plants. Previous studies analyzed FDG translocation and distribution pattern in plants and proposed that FDG could be used as a tracer for photoassimilates in plants. Elucidating FDG metabolism in plants is a crucial aspect for estab...
متن کاملan improved synthesis and preliminary biodistribution study of a technetium-99m-labeled 2-amino-2-deoxy(thioacetyl)-d-glucose complex ([99mtc]-ta-dg) as a tumor imaging agent
introduction: this report describes the synthesis of 2-amino-2-deoxy(s-benzoylthioacetyl)-d-glucose (s-bz-ta-dg), radiolabeled with [99mtc(co)3(oh2)3]+ complex with a procedure including deprotection of the benzoyl group, characterization by hplc using a c18 reverse phase column and preliminary biodistribution study in normal mice. methods: [99mtc(co)3(h2o)3]+ complex was used to label ta-dg w...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2020
ISSN: 2399-5300
DOI: 10.1093/geroni/igaa057.3267